Unconventional organelles – biological condensates and crystal biology

I study a simple question that turns out to be surprisingly nontrivial:

Why do cells build crystals?

For more than a century, since Charles Darwin and Ernst Haeckel, intracellular crystals were often regarded as passive waste products or cellular curiosities. My research has shown that these structures can serve as nutrient reservoirs, optical devices, regulators of metabolism, and potentially key players in global biogeochemical cycles.

By combining protistology, spectroscopy, microscopy, genetics, structural biology, photonics, and environmental biology, I investigate the formation, function, and evolution of biogenic crystals across microbial eukaryotes.

My long-term goal is to establish a unified framework connecting:

genes → molecular self-assembly → crystal formation → cell physiology → ecosystems → global biogeochemical cycles and Earth system processes

By understanding why cells build crystals, we may uncover previously hidden principles that shape life across scales, from molecule to structure to organelle to ecosystems 

Redefining Strontium and Barium Cycling

Redefining Strontium and Barium Cycling

We discovered massive accumulation of barium and strontium in marine diplonemids.

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Nitrogen Storage Through Crystals

We contributed to the discovery that guanine crystals serve as dynamic nitrogen reserves in microalgae.

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Finding new localization of polyphosphate in chloroplasts of zygnematophytes

Finding new localization of polyphosphate in chloroplasts of zygnematophytes

Unexpected localization in chloroplasts rather than specialized acidocalcisomes known from other species, polyphosphate could be one of the major adaptation advantages in the terrestrialization process of zygnematophytes, the sister group of land plants.

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Crystal-Based Microbial Vision

Crystal-Based Microbial Vision

We showed that guanine crystals function as photonic mirrors in microbial eyespots. This discovery opened a completely new direction at the interface of cell biology, optics, and materials science.

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A Paradigm Shift in Biocrystallization

A Paradigm Shift in Biocrystallization

We demonstrated that purine crystals are widespread throughout eukaryotes and likely more abundant than previously recognized inorganic biominerals.

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Mailing Address

Mikrobiologický ústav AV ČR, v.v.i
Centrum ALGATECH

Novohradská 237 - Opatovický mlýn
379 01 Třeboň
Česká republika

Contacts

Secretariat:

Phone: +420 384 340 412
E-mail: info@alga.cz

We are ALGAGECH

The Czech Academy of SciencesInstitute of Microbiology of the Czech Academy of ScienceseuInterreg EUopvavpiopvk