Main research interest

 

On the beggining of my study, I was dealing mainly with taxonomy and ecology of freshwater cyanobacteria and algae. I participated in many field works containing microscopic determination of species from different habitats. Later, I started to focus on the cyanobacterial secondary metabolites with biological activity on cancer cell lines. My main interest is testing of compounds isolated from cyanobacteria on cancer lines in vitro and investigate their mechanism of action and the type of cell death, especially apoptosis. My biggest interest is currently aimed at metabolomics and flow cytometry. 

 

Scientific expertise

 

Taxonomy of algae and cyanobacteria; cell cultures; cell based assays; fluorescence microscopy, preparation of metabolomic and proteomic samples. Marginally HPLC-HRMS and flow cytometry.

 

Education

• 2018–now University of South Bohemia, C. Budejovice, Czech Republic. Faculty of Science. Infection biology. PhD degree. Topic: Study of anticancer activity of cyanobacterial secondary metabolites.
• 2016–2018 University of South Bohemia, C. Budejovice, Czech Republic. Faculty of Science. Physiology and developmental biology of animals. PhD degree. Topic: Study of anticancer effects of cyanobacterial secondary metabolites using rat WB epithelial liver cells transformed with Ras oncogene.
• 2014–2016 University of South Bohemia, C. Budejovice, Czech Republic. Faculty of Science. Botany - Bionomy of cyanobacteria and algae. Master degree. Thesis: Toxicological potential of benthic nostocal cyanobacteria.
• 2010–2013 University of South Bohemia, C. Budejovice, Czech Republic. Faculty of Science. Biology. Bachelor degree. Thesis: The floristic-ecological study of selected areas of  the Czech Canada.
• 2007–2010 The College of Higher Education in Nursing, Pilsen, Czech Republic. Thesis: The blood parasites – malaria and sleeping sickness.

Key current international cooperation

• Dr. André Mueller (Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria)

Teaching and tutoring

• 2016–2020 Teaching at University of South Bohemia, Czech Republic:
  • Field Work I – Algology
  • Phycology (Algology) – excercise
  • Natural bioactive compounds – excersise

Ongoing student supervision

• 2019–now Brozova V. A comparison of the effects of tolytoxin and its structural variant on cancer and primary cell lines. Department of Botany, Faculty of Science, University of South Bohemia – Bc. supervisor